Can the Biggest Loser solve our New Year’s Resolution?

Maybe, like me, you’re a couple of weeks into your New Year’s Resolution. I hope it’s going well. If your resolution centers on weight, let me suggest a strange source of motivation to continue. You may remember the dozen-year run of the NBC reality TV series The Biggest Loser. Contestants engaged in brutal exercise regimens and draconian calorie restriction (65%!) in an office-style weight loss competition, but only if your office manager trained under a third-world dictator and wore spandex. Through a 2022 prism, the show is horrifying, with its subtext that the value of the contestants as people was inextricably linked to their success in a crash diet and our knowledge that contestants abused diuretics for the sake of losing a few extra pounds for their public weigh-ins. The long-term weight-maintenance success rate of the contestants was, to put it mildly, not high.

So, I hope that any health-oriented 2022 resolutions bear little in common with The Biggest Loser. If you’re working on weight reduction, I hope you’ll focus more on the journey than the destination. But I also hope that we can all take a few lessons from the contest. A small number of contestants actually kept significant weight off after leaving the show, and a new analysis by Kevin Hall of NIH, maybe the most influential metabolic researcher in the world, looks at what may have led to their sustained success.

One of the major challenges in weight reduction is that we all gravitate toward a weight “set point” that is determined fairly early in life. When we lose a lot of weight, a la The Biggest Loser contestants, our resting metabolic rate–the calories we burn just to breathe, think, and live–slows significantly, and it becomes ever harder for us to keep weight off as our physiology inevitably pushes us back toward that set point. Investigators call this “metabolic adaptation.”

Distressingly, Hall found that six years after the competition ended, former contestants who maintained a very meaningful 12% weight reduction still exhibited a ~500 kcal/day metabolic adaptation. That is, their bodies burned 500 calories per day less at rest than they had prior to their weight reduction. And, paradoxically, the people who had the highest levels of physical activity (i.e., those who continued to burn the most energy through exercise) had the largest reductions in basal metabolic rate even though they were also the group who kept off the most weight. We can only conclude that physical activity not only burns extra calories but may have an effect on appetite. Other mechanisms are possible as well. It’s a big unknown.

Regardless of the uncertainty, this is even more evidence that we should focus more on the process of healthy living than we do on any individual measure, like body weight, waist circumference, or pant size. As we’ve said before, patients who enter programs like the Diabetes Prevention Program are often surprised at how little their weight is mentioned in class compared to, say, their daily activity levels. As you struggle with your resolution this year, consider altering your strategy if things get tough. Instead of saying “I’m going to lose five pounds this month,” consider process-based SMART objectives, like eating at least five servings of fruits and vegetables daily, taking a tablespoon of psyllium husk daily, and at least 30 minutes a day of real physical activity.

And if you’re interested in promoting this kind of strategy to your employees through resources like the Diabetes Prevention Program, please let us know.

As the Medical Director of the Kansas Business Group on Health, I’m sometimes asked to weigh in on hot topics that might affect employers or employees. This is a reprint of a blog post from KBGH.

Focus on the Process, Not the Outcome

Imagine, if you dare, that you are Kansas City Chiefs Head Coach Andy Reid. Fresh off two Super Bowls (and almost a third), your team now sits at 3 wins and 4 losses after a blowout defeat in which you scored zero touchdowns. You could indulge in self-pity and just listen to radio talking heads conjecture on your anticipated win-loss record come Thanksgiving.

But if your Andy Reid cosplay is true to form, I’d bet dollars-to-donuts that, instead of focusing on that intermediate outcome, you’d spend the next practice working on the process to make a better outcome more likely: fundamental skills like making sure players line up in the proper formation, know their assignments, and use sound technique in blocking, tackling, throwing, and catching. I’d bet you would want to make sure your players take care of nagging injuries.

Let’s think about the ultimate goals of medical care through this process-oriented lens. As we’ve outlined before, every medical test or treatment should aim to accomplish at least one of the following goals:

  1. It makes the patient feel better.

  2. If it does not make the patient feel better, the test or treatment should make the patient live longer.

  3. Finally, if a test or treatment makes no difference in how the patient feels and makes no difference in how long the patient lives, it should at the very least save money.

If a diagnostic or therapeutic strategy can’t be proven to cause #1, 2, or 3, it isn’t worth pursuing. In this framing, weight loss is a winner: it clearly meets criterion #1. Not only does weight loss increase one’s self-esteem come bikini season (at least according to literally every magazine cover I’ve ever seen in the checkout aisle of a supermarket), it reduces the risk of multiple potentially debilitating chronic diseases, and it eases joint pain. And, as has been repeatedly shown by programs such as the Diabetes Prevention Program, which we push hard at KBGH as part of our work with CDC and KDHE, weight loss saves money (criterion #3). But in terms of #2, life prolongation, weight loss has historically fallen short. And prolonging life is maybe the thing doctors are most proud of, given our 40-year extension of life expectancy in the developed world in the last century or so.

This is a paradox.

An excellent review published this week took on this paradox head-on and concluded that interventions for obesity would be more effective at preventing early death if they focused less on weight loss and more on increasing physical activity and improving fitness levels. That is, talk less about the outcome of a reduced body weight in six or twelve months, and talk more about the physical activity that will help the patient get there:

iScience

As you can see above, for any given weight, you’re less than half as likely to die of any cause if you’re cardiovascularly “fit” than if you’re not cardiovascularly fit (the word “unfit” seems a little pejorative here, but maybe that’s just me).

This isn’t necessarily new news. We’ve known for a long time that the things that happen in doctors’ offices that truly prolong life are surprisingly limited. But they’re powerful, and physical activity promotion is right there with cholesterol management, blood pressure control, and smoking cessation in terms of its potential to make people live longer. Physical activity reduces your risk of death from any cause by about 23% in a given period of time. Focusing on the process of being active daily achieves the outcome–the outcome we’re all ultimately most interested in–of a reduced risk of death, even without taking into account weight reduction.

Journal of the American Medical Association

This approach of process-over-outcomes and health at any size is provocative, but it is gaining steam. We’ll hear several speakers address the topic at the upcoming KBGH-sponsored Live Well with Diabetes Day of Discovery Event. Just as Andy Reid is surely telling his players to focus on their skills and decision making and not on their wins and losses, those speakers will likely tell us to start paying more attention to physical activity and food choices and less attention to the scale.

As the Medical Director of the Kansas Business Group on Health, I’m sometimes asked to weigh in on hot topics that might affect employers or employees. This is a reprint of a blog post from KBGH.

COVID-19 May Be Worse in the Fall. The Time to Protect Yourself is Now.

The rate of new COVID-19 cases is finally headed downward again in Kansas:

Statnews.com

Statnews.com

We’re not through this yet.

With fall comes cooler weather and seasonal influenza stacked on top of the COVID-19 pandemic. This looming threat is causing foundational changes in our expectations of the season. Several college conferences have already cancelled sports. Theater releases of movies that cost hundreds of millions of dollars to produce have been delayed indefinitely, and others have gone straight to video on demand. The spookiness of the Halloween season is real, and getting realer every day.

So we and our employees should continue masking. Masking works (as long as the mask isn’t a fleece buff). We should continue socially distancing whenever possible, and we should obviously get vaccinated against seasonal influenza when we can. We should get the COVID-19 vaccine as soon as it is available. But what else can we do?

We can lose weight. Real disaster preparedness isn’t hoarding water or ammunition. It is largely the preparation of your body and your bank account for emergencies. A recent study in the Annals of Internal Medicine found that, especially in people younger than 65, obesity was one of the biggest risk factors for intubation and death with COVID-19. And the bigger patients were, the higher the risk. “Morbidly” obese COVID-19 patients–those with a body mass index, or BMI, of 40 kg/m2 or greater–were 60% more likely to die or require intubation, compared with people of normal weight:

Annals of Internal Medicine

Annals of Internal Medicine

And obesity may even decrease the effectiveness of a future SARS-CoV-2 vaccine.

So if you are one of the roughly 40% of Americans who are obese, then to protect yourself this fall, the time to start reducing risk is now. This isn’t about judgement or shaming. I’ve been very vocal in the past about my disdain for the opinion that obesity is some personal or moral failing. It is not. It is a product of genetics and environment, just like heart disease, cancer risk, and yes, risk for infections.

How can you, as an employer, help your employees reduce risk beyond vaccination?

Traditional worksite wellness programs are disappointing, unfortunately, although as we’ve blogged about in the past, some worksite strategies for weight loss have proven modestly effective around the holidays. And restricting one’s diet to “unprocessed” foods such as those in Group 1 of the NOVA Food Classification System appears to result in weight loss even without intentional dieting. If we take the problem seriously, though, we’re inevitably led to the question of coverage of weight loss programs like the Diabetes Prevention Program, coverage of weight loss medications, and coverage of bariatric surgery. [Disclaimer: KBGH is funded in part by two CDC grants that aim to identify obese or pre-diabetic people and refer them into programs like the Diabetes Prevention Program that help them lose weight and reduce their risk.]

If you’re not already covering these benefits, consider them the next time you update your employee benefits. And, as always, if KBGH can be any help in determining the potential benefits to your employees from these programs or treatments, please contact us!

As the Medical Director of the Kansas Business Group on Health I’m sometimes asked to weigh in on topics that might affect employers or employees. This was a reprint of a blog post from KBGH.

Links for Wednesday, September 5, 2018: docs are nervous about weight loss meds, risky low-carb diets, why I'm not a pediatrician, and continuity of care is good

Why don't more docs prescribe weight loss medications?

Speculation: 1) cost (and by extension, prior authorization requests); 2) residual fear from fen-phen, as one of the docs interviewed alluded to. We can surely put this to bed, since the current crop of meds has been on the market much longer than fen-phen had been when its harm was revealed; 3) nihilism. Five percent weight loss is meaningful from a medical perspective, but unless the doc is consciously, prospectively measuring outcomes like blood pressure, lipids, and fasting sugars, it won't knock her socks off. Patients won't be thanking her for getting them ready for bikini season; and 4) the old Risk Evaluation and Mitigation Strategy (REMS) for Qsymia was such a PIA that it scarred some docs to prescribing these meds.

Can we stick a fork in low-carbohydrate diets? (Ba Dum Tss)

What's a 32% increase in mortality among friends? Investigators (in a study that, to my knowledge, has not yet been published, so caveat emptor) found an association between the lowest quartiles of carbohydrate intake and death:

NHANES data. Model 1 is unadjusted for other risk factors. Model 2 is adjusted. These are ugly, ugly numbers. 

NHANES data. Model 1 is unadjusted for other risk factors. Model 2 is adjusted. These are ugly, ugly numbers. 

Remember: we can't draw causality from this. There is some chance that people who are sick and more likely to die from heart disease, cancer, or stroke are more likely to adopt low-carbohydrate diets. But it doesn't seem likely. The people at highest risk in this study were those over age 55 and "non-obese."

Reason # 1,001 I'm not a pediatrician:

Can. Not. Do. It.

Special shout-out to the 100 cell phone text alerts during the video. 

If lack of continuity is a mark against telemedicine, then it's a mark against the hospitalist model in general

My remarks from the Wichita Business Coalition on Health Care's Obesity Forum this morning

Thanks for inviting me to kick off this very important event. Let’s start with a healthy dose of intellectual honesty. Obesity is a disease. It has arguably been so since the beginning of time, but it was made official in this country in 1985 when the National Institutes of Health issued a statement following its Consensus Development Conference on Obesity. This was followed by the report of the World Health Organization’s Consultation on Obesity and then the report of a committee of the Institute of Medicine, now known as the Health and Medicine Division of the National Academy of Sciences. Finally, the American Medical Association in 2013. Obesity is a disease because it is a “definite, morbid process with characteristic symptoms which affects the entire body; and has a known pathology and prognosis.” Obesity shouldn’t need this label in order to be taken seriously. Whether we--our institutions and organizations--pay for obesity treatment should ultimately depend more on what outcomes we value and the cost of achieving those outcomes. That is, the material inputs and outputs of the process, not our opinions of the people or behaviors that lead to them. A materialist versus spiritualist argument. I recently spoke at the Chronic Disease Alliance of Kansas meeting. Some of you were there. I made the argument that even if you are a spiritualist by nature, if you’re interested in medicine or public health, you must invest in a materialist point of view. That means you have to provide evidence for your assertions. How does this little philosophical cul-de-sac apply to obesity? Because I would argue that in spite of ample evidence and the label of disease applied by the NIH, the National Academy of Sciences, the AMA, and others, we don’t treat obesity in this country as a disease.

Think of what happens if you have, say, osteoarthritis of the knee. If you go to the doctor complaining of knee pain that fits the pattern of knee osteoarthritis, within some small confidence interval, you’ll get the same treatment regardless of what doctor you visit: x-rays to confirm the diagnosis, then some initial combination of anti-inflammatory drugs plus or minus strength training or physical therapy; then possibly an injection of hyaluronate or another agent; then a surgical procedure. All backed by some degree of clinical evidence as to their efficacy, with a set of professional guidelines that dictate the order and intensity in which they’re used.

And treatment for the disease--osteoarthritis still--is not limited to the clinical environment. We live under a robust set of laws, regulations, and expectations surrounding the humane treatment of people with osteoarthritis: handicapped parking stalls, construction standards around accessibility (curb cuts and whatnot). Furthermore, an enormous industry exists which caters to osteoarthritic people’s needs: handrails, higher toilets, special bathtubs, purpose-designed kitchen utensils, and others. For all its imperfections, this set of guidelines and expectations has the hallmarks of science: organization of knowledge, adaptability, the ability and willingness to change as evidence evolves.

But what happens if a patient goes to see his or her doctor for obesity? Even if the patient is lucky enough to encounter a doctor that considers obesity a disease and not a personal character failing, no such predictability exists. Doctor one may prescribes meal replacements, a la Nutrisystem, Weight Watchers, or dozens of competitors. Doctor two recommends avoiding “carbs.” (once called Atkins, now called paleo or ketogenic diet; it never goes away, we just change the name every ten years or so to convince people to avoid whole grains, the single most protective dietary component against diabetes) Doctor three prescribes phentermine, or if the patient is lucky, one of the drugs actually approved by the FDA for weight loss, all of which are exorbitantly expensive and modestly effective. Doctor four recommends the Diabetes Prevention Program. Doctor five recommends bariatric surgery. Doctor six recommends probiotics or another microbiome-directed treatment.

When the patient leaves the doctors office, she enters a built environment designed to be maximally obesogenic. Four-lane arterial roads replacing walkable, bikeable streets, even though we know beyond certainty that trips taken by car, rather than by bike, foot, or public transportation, are perfectly, directly related to the obesity rate in any community. And the amount of money any community spends on car-related transportation is perfectly aligned with obesity rates. Our patient pays sales taxes on obesogenic foods (red meat, refined carbohydrates, sugared beverages, and fats) at exactly the same rate as protective, high-fiber, unprocessed fruits, vegetables, and whole grains, in spite of evidence that Pigovian taxation, in which unhealthy foods are taxed at a rate equal to their the social cost and healthy foods are subsidized, has a powerful effect. Similarly, crop insurance and subsidy programs--in whatever form they take--favor meat and dairy production over fruits and vegetables.

When a peer gets cancer, we offer words of encouragement and give her rides to the doctor. We judge those with obesity and say they’re getting what they deserve for their weakness and sloth. We consider people who are competent, functioning members of society to be somehow constitutionally flawed and subject them to various levels of social discrimination. Obesity, along with intelligence, seems to be one of the final acceptable targets of discrimination; we casually make jokes about fat people and stupid people with none of the anxiety that accompanies insensitive remarks about race or sexual orientation. This is surely short-lived; over 80 million people in the U.S. have an I.Q. less than 90, and over 100 million are obese by body mass index criteria. These are groups large enough to fight back.

Viewed by an outsider, this set of circumstances does not resemble science. This is not the end result of a materialist view of the world. It resembles religion: a cultural system of competing behaviors, world views, and ethics that relate humanity’s problems not to the laws of the universe, but to supernatural elements. This elevation of the spiritual realm above the material realm is perfectly fine on Sunday mornings. I’m not here to make an anti-religion argument. Religion and spiritualism are vital in mobilizing public passion and opinion. NIH director Francis Collins, who discovered the gene mutation responsible for cystic fibrosis and later directed the Human Genome Project, is an evangelical Christian who advocates that religious belief can not only be reconciled with acceptance of scientific evidence, but that spirituality is vital to the responsible advancement of science. But spiritual thought in the absence of material evidence is unacceptable in the pursuit of a public health solution.

So how should we handle obesity as a health problem? As Kansans, we’re lucky to have perhaps the best model in our collective memories. We have Samuel Crumbine, early 20th century Dodge City physician who revolutionized the treatment of tuberculosis and other infectious diseases. At the outset of Dr. Crumbine’s career, infections were the leading cause of death by far and were dealt with in a quasi-spiritual manner. The consumption of tuberculosis was seen as God’s wrath. But Dr. Crumbine applied common sense strategies to limit the spread of the disease. He helped established sanitaria for tuberculosis patients, to isolate them from the public until they were no longer contagious. He spearheaded laws against spitting on the sidewalk (remember the bricks?), against shared drinking cups (you have him, indirectly, to thank for the modern bubbler-style drinking fountain), and against shared towels in public bathrooms. He advocated for fly-swatting campaigns. And all the while, he still promoted medical interventions for people already infected. Better antibiotics were developed. The entire specialty of cardiothoracic surgery grew not out of a need for coronary artery bypass grafting, but out of the need to drain tuberculous abscesses from the chests of infected patients.

When applied to obesity, I’m aware that lines blur. Calling something a disease moves individuals across a gauzy barrier between personhood and patienthood. You’re a person up until you’re labeled with a disease, then you’re a patient. The label inherently causes the patient to adopt a role in which he or she is excused from responsibility for his/her condition. This is healthy and appropriate; we know that the vast majority of lung cancers are caused by cigarette smoking, but we do not argue that smokers should be denied treatment. And the label creates an obligation for treatment that many obese people may not want. Roxane Gay and others have argued eloquently against the over-medicalization of body weight. And if this process (labeling of a disease, applying that label to people) entails an obligation for treatment, who will consent to pay the costs for that treatment? This social negotiation is just as big a part of what we need to address as any specific decision on the appropriateness or order of interventions.

I’m no Samuel Crumbine. I don’t even have a mustache. But if I channel Dr. Crumbine, I can see continued progress starting today. I can see the further development of a bike and pedestrian infrastructure, sensible parking policies, and street design that encourages higher density development with widely available green spaces. This can be partnered with local laws and regulations, a more sensible crop subsidy program, and a food tax system that encourages the production and consumption of quality foods over obesogenic foods. For patients who choose to seek help from their doctor, I can see a set of community-wide standards that promote a practical, stepwise approach to treatment that incorporates dietary and behavioral interventions alongside policies that make proven drug and surgical interventions more affordable. I can advocate for the development of a unified, science-based approach to obesity, motivated by spirituality but guided by material evidence.

Disclaimer: Health ICT was also a presenter, and the Forum was supported through a grant offered by the National Alliance of Healthcare Purchaser Coalitions and Novo Nordisk.